Todd Phillips' sequel returns Joaquin Phoenix in the titular role, only this time he is joined by Lady Gaga in a genre-busting, music-infused movie.

Folie à Deux is set after Arthur Fleck (Joaquin Phoenix) shoots Murray Franklin (Robert De Niro) dead on his live talk show. Arthur Fleck is institutionalised at Arkham Asylum as he awaits the trial for his crimes as Joker.

In Joker: Folie à Deux, Lady Gaga stars as Harley Quinn opposite Joaquin Phoenix’s Arthur Fleck/Joker. The film—which is part jukebox musical and part crime drama—is the sequel to the 2019 blockbuster hit Joker, which earned Phoenix a Best Actor Oscar.

Joker: Folie à Deux' eyes $140M global start at the box office, well below the near $249M global start of first 'Joker' in 2019.

Can we truly grasp how many people live inside us—or who we could become? There are moments, as we look in the mirror—much like Arthur Fleck does—when the reflection staring back feels alien, a stranger wearing our skin.

Lady Gaga and Joaquin Phoenix were among the stars on had for the Joker: Folie a Deux premiere in Los Angeles Monday evening.

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Joker: Folie a Deux had grandeur written all over it. Nobody is surprised that Joaquin Phoenix owns every frame. And, while Lady Gaga's terrifying screen presence left everyone wanting more, her past several film appearances have solidified her status as a bankable performer.