A change could be coming soon to the 49ers' defense. So far this season the 49ers have been starting veteran cornerback Isaac ...

A familiar face is set to return to the San Francisco 49ers' linebacking core. On Tuesday, the team announced the signing of ...

The 49ers called their win over the Patriots this past Sunday a work of art. Was it really, though? NFL.com's Eric Edholm ...

The legendary quarterback and Bay Area native will be in the booth on Sunday in Santa Clara for the San Francisco 49ers’ week ...

It’s worth noting the Patriots’ offensive line is putrid and that most of the 49ers’ defensive front cooked against them.

The 49ers' defensive line embracing a strength-in-numbers approach sparked San Francisco's dominant performance in Sunday's ...

A matchup with the banged-up, struggling New England Patriots was just what the San Francisco 49ers needed following ...

Fox is sending top NFL analyst Tom Brady back to his Bay Area home this weekend to call his first San Francisco 49ers game in ...

In Week 5, running back Trey Benson and the Arizona Cardinals' ground attack will match up with the San Francisco 49ers and ...

San Francisco 49ers star running back Christian McCaffrey has bilateral Achilles tendinitis, meaning he has it in both legs, ...

When the San Francisco 49ers (2-2) and Arizona Cardinals (1-3) play on Oct. 6 at Levi's Stadium, Brock Purdy and Kyler Murray ...

SportsLine's model simulated New England Patriots vs. San Francisco 49ers 10,000 times and made its Week 4 NFL picks, ...